Malaria remedies of the Kenyah of the Apo Kayan, East Kalimantan, Indonesian Borneo: A quantitative assessment of local consensus as an indicator of biological efficacy
Identifieur interne : 002A94 ( Main/Exploration ); précédent : 002A93; suivant : 002A95Malaria remedies of the Kenyah of the Apo Kayan, East Kalimantan, Indonesian Borneo: A quantitative assessment of local consensus as an indicator of biological efficacy
Auteurs : Danna J. Leaman [Canada] ; J. Thor Arnason [Canada] ; Razali Yusuf [Indonésie] ; Harini Sangat-Roemantyo [Indonésie] ; Herwasono Soedjito [Indonésie] ; Cindy K. Angerhofer [États-Unis] ; John M. Pezzuto [États-Unis]Source :
- Journal of Ethnopharmacology [ 0378-8741 ] ; 1995.
English descriptors
- Teeft :
- Aglaia, Aglaia dookoo, Aistonia scholaris, Alkaloid, Alstonia, Alstonia scholaris, Alternate hypothesis, Antimalarial, Antimalarial activity, Antimalarial drugs, Antiplasmodial, Antiplasmodial activity, Aqueous ethanol, Arnold arboretum, Asample numbers, Bark bark, Bark extracts, Betle, Biological activity, Biological efficacy, Biological samples, Borneo, Brine shrimp, Burkill, Carica papaya, Ceiba pentandra, Chai, Chemical society, Chinensis, Chloroquineresistant clone, Chypothesis tests, Clone, Control remedy, Crude extracts, Cytotoxic activity, Dart poison antidote, Demam kora, Different extracts, Different letters, Domesticum, East kalimantan, Economic botany, Effective antimalarials, Effective treatments, Eliator, Eriodendron anfractosum, Ethnopharmacology, Etlingera, Extract, Fagraea racemosa, Falciparum, Falciparum clone, Falciparum clones, Field trials, Fish poison, Further investigation, Further research, Gastrointestinal ailments, Good indicator, Harvard university, Herbarium bogoriense, Homalomena pendula leucosyke alba parkia speciosa plectranthus scutellaroides pongamia pinnata smilax barbata, Human epidermoid carcinoma, Importance value, Importance values, Indonesian, Indonesian borneo, Indonesian institute, Initial absorbance, Insect stings, International journal, Kayan, Kayan kenyah, Kayan villages, Kenyah, Kenyah malaria, Kenyah malaria remedies, Kenyah malaria remedy, Lansium, Lansium domesticum, Leaman, Letter ranges, Lidung payau, Local consensus, Long ampung, Long sungai barang, Malaria, Malaria remedies, Malaria remedy, Malaria remedy extracts, Malay, Malay peninsula, Medicinal, Medicinal plants, Metzger, Mosquito bites, Multiple comparison, Muricata, Natural products, Natural sources, Nature indonesia programme, Nicolaia eliator, Null hypothesis, Other ailments, Other extracts, Other types, Papaya, Periodic fevers, Phytochemistry, Piper, Piper arborescens, Piper arborescens piper betle premna, Piper betle, Planta medica, Plasmodium, Plasmodium falciparum, Pothos ovatifolius engl, Quantitative analysis, Quantitative assessment, Remedy, Remedy extracts, Remedy importance value, Resident physician, Rhizome, Root bark, Royal botanic garden, Sarawak, Sarawak museum journal, Schefflera, Scholaris, Screen concentrations, Selective activity, Selective antiplasmodial activity, Significant activity, Significant reduction, Spleen, Spleen fever, Splenomegaly, Standard error, Subsequent tests, Test extracts, Traditional knowledge, Traditional remedies, Tropical plants, Unidentified, Useful plants, Viability, Viability determinations, Vivo antimalarial activity, World health organization.
Abstract
Abstract: Traditional remedies have been a source of important antimalarial drugs and continue to provide novel and effective treatments, both where pharmaceuticals are not available and where the disease is increasingly resistant to commonly prescribed drugs. The Kenyah of the Apo Kayan, a remote forested plateau in Indonesian Borneo, use 17 malaria remedies derived from natural sources. A quantitative analysis of the relationship between a ‘local importance value’ index for each malaria remedy (IVmal) and inhibition of cultured Plasmodium falciparum by ethanolic extracts supports the hypothesis that the degree of local consensus about a given remedy is a good indicator of its potential biological efficacy. Our results confirm the rational selection and use of traditional remedies for malaria by the Kenyah. We have identified target species for further research directed toward safe and effective treatments for malaria.
Url:
DOI: 10.1016/0378-8741(95)01289-3
Affiliations:
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remedy</term><term>Crude extracts</term><term>Cytotoxic activity</term><term>Dart poison antidote</term><term>Demam kora</term><term>Different extracts</term><term>Different letters</term><term>Domesticum</term><term>East kalimantan</term><term>Economic botany</term><term>Effective antimalarials</term><term>Effective treatments</term><term>Eliator</term><term>Eriodendron anfractosum</term><term>Ethnopharmacology</term><term>Etlingera</term><term>Extract</term><term>Fagraea racemosa</term><term>Falciparum</term><term>Falciparum clone</term><term>Falciparum clones</term><term>Field trials</term><term>Fish poison</term><term>Further investigation</term><term>Further research</term><term>Gastrointestinal ailments</term><term>Good indicator</term><term>Harvard university</term><term>Herbarium bogoriense</term><term>Homalomena pendula leucosyke alba parkia speciosa plectranthus scutellaroides pongamia pinnata smilax barbata</term><term>Human epidermoid carcinoma</term><term>Importance 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The Kenyah of the Apo Kayan, a remote forested plateau in Indonesian Borneo, use 17 malaria remedies derived from natural sources. A quantitative analysis of the relationship between a ‘local importance value’ index for each malaria remedy (IVmal) and inhibition of cultured Plasmodium falciparum by ethanolic extracts supports the hypothesis that the degree of local consensus about a given remedy is a good indicator of its potential biological efficacy. Our results confirm the rational selection and use of traditional remedies for malaria by the Kenyah. We have identified target species for further research directed toward safe and effective treatments for malaria.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Indonésie</li><li>États-Unis</li></country><region><li>Illinois</li></region><settlement><li>Chicago</li></settlement><orgName><li>Université de l'Illinois à Chicago</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Leaman, Danna J" sort="Leaman, Danna J" uniqKey="Leaman D" first="Danna J." last="Leaman">Danna J. Leaman</name></noRegion><name sortKey="Arnason, J Thor" sort="Arnason, J Thor" uniqKey="Arnason J" first="J. Thor" last="Arnason">J. Thor Arnason</name></country><country name="Indonésie"><noRegion><name sortKey="Yusuf, Razali" sort="Yusuf, Razali" uniqKey="Yusuf R" first="Razali" last="Yusuf">Razali Yusuf</name></noRegion><name sortKey="Sangat Roemantyo, Harini" sort="Sangat Roemantyo, Harini" uniqKey="Sangat Roemantyo H" first="Harini" last="Sangat-Roemantyo">Harini Sangat-Roemantyo</name><name sortKey="Soedjito, Herwasono" sort="Soedjito, Herwasono" uniqKey="Soedjito H" first="Herwasono" last="Soedjito">Herwasono Soedjito</name></country><country name="États-Unis"><region name="Illinois"><name sortKey="Angerhofer, Cindy K" sort="Angerhofer, Cindy K" uniqKey="Angerhofer C" first="Cindy K." last="Angerhofer">Cindy K. Angerhofer</name></region><name sortKey="Pezzuto, John M" sort="Pezzuto, John M" uniqKey="Pezzuto J" first="John M." last="Pezzuto">John M. Pezzuto</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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